My intent in creating this blog is to document my observations during a high dosage resveratrol program which I anticipate will last for six months. I am taking a 1000mg daily dose of a pure resveratrol product I purchased from Bioflu.com. I chose this one because it was the only pure, high-potency supplement I could find that supplies the level of resveratrol and especially trans-resveratrol that I need to conform to the recently published studies on mice that showed a 30% increase in lifespan and a 100% increase in endurance.

I started supplementation today. My initial dose is 1.0

gm of polygonum cuspidatum assayed as 50% resveratrol, virtually all of which is the trans-resveratrol isomer. I selected this rather high dose to begin my program as it roughly corresponds to the human equivalent of the dosage given to mice in at least one credible study when an upward adjustment is made for the difference in body mass further adjusted in the opposite direction for the relatively slow metabolic rate of a human versus that of a mouse. Admittedly this is an approximation however, given the absence of authoritative data regarding exactly what an efficacious dose is for an adult person, I had no reference against which to evaluate the proper first dose. My rationale for the 1.5 gm amount is simply that it is the maximum amount of resveratrol that I am willing to ingest on a daily basis for the period of this one-person trial. My intention is to continue this daily dosage for a period of six months unless I experience moderate to serious adverse side effects or I believe that my present high level of health and fitness is being compromised or negatively impacted as a result of the trial. I do not profess that this is a scientific or otherwise valid investigation of the effects of resveratrol on even this one human, let alone anyone else. It is simply an experiment motivated by my own curiosity, fear of death and a hunch that the results obtained in numerous studies over several years beginning with flat worms and now evident in small mammals may translate to humans. I readily confess that any positive results I might obtain could reasonably be attributed to the placebo effect however given the amount of supplements I am presently taking and have been taking for approximately 20 years it is difficult for me to imagine that I have not already exhausted this effect. Furthermore, I am happy to take whatever I get in terms of benefits even if they are later proved to be the product of my own unfounded confidence in resveratrol.

Observations: Dark yellow urine, not the color of urine after taking a multi B supplement, a bit darker and slightly reddish.

Day 2

12/12/2006

Nothing of significance to record today. Did a short session at the gym. During my workout today I felt sluggish and decided to cut it a bit short. Not certain if this is a result of the resveratrol of due to the fact that I have not been able to get my normal 8 hours of sound sleep over the past week due to my workload. I have read accounts of res users who experienced some stomach upset during the first couple of days on the supplement. I have not found this to be the case even though my dosage is extremely high.

Observations: None of any consequence